Efeito de uma sessão de exercício resistido isométrico na reatividade vascular de pessoas com cirrose hepática

Abstract

In patients with hepatic cirrhosis, there is an exacerbation of peripheral endothelial function, leading to a marked production of NO and exaggerated peripheral vasodilation. Evidence suggests that isometric palmar grip exercise can induce either vasodilatory or vasoconstrictor responses. The study aimed to assess the effect of a session of isometric palmar grip exercise on muscle blood flow (MBF) at rest and in the response to reactive hyperemia in patients with hepatic cirrhosis. Fourteen hepatic cirrhosis patients, comprising 12 men and 2 women in Child A category, were recruited. MBF was evaluated using venous occlusion plethysmography, and blood pressure was measured in the dominant arm with the Dixtal 2022 multiparametric monitor, both at rest and during isometric exercise. Forearm vascular conductance (FVC) was calculated by dividing MBF by mean arterial pressure, multiplied by 100, and reported in units. The results indicated that MBF and FVC were similar both at rest pre- and post-isometric exercise session (3.46±1.43 vs. 2.94±2.03 ml/min/100ml, p=0.148, and 3.71±1.45 vs. 3.11±2.04 units, p=0.184, respectively).Analyzing the response to reactive hyperemia, a similar increase in MBF from rest to reactive hyperemia was observed both pre- and post-isometric exercise session (pre-session: 3.46±1.43 vs. 16.1±9.55 vs. post-session: 2.94±2.03 vs. 14.4±12.5 ml/min/100ml, respectively; time effect: p<0.001; session effect: p=0.530, and interaction effect: p=0.694).In conclusion, the isometric exercise session did not alter MBF at rest, and it had no impact on the response to reactive hyperemia in patients with hepatic cirrhosis.