Complexos metálicos de tiossemicarbazonas: uma visão atual sobre a estrutura e a atividades biológicas desses compostos.

Abstract

Thiosemicarbazones (TSCs) are synthetic compounds that have several pharmacological activities listed in the literature. They can bind metals, due to the presence of atoms with free electron pairs (N, S) in their skeleton. Furthermore, in many situations their metal complexes are more active than free TSCs. The increase in the number of studies relating the activity of TSC complexes has motivated the appearance of review articles that highlight their role, both from the point of view of coordination chemistry and the relationship between their chemical structure and biological activity. In this work a synthesis of recent results from researchers investigating the biological properties of TSC complexes is reported. The evaluated data focus on the main modes of coordination of TSCs to metals (bidentate and tridentate), with more than 100 works published in the last 10 years being selected. It was observed that the choice of metal may be related to the fact that the TSC used is tridentate or bidentate. There is also a tendency for the complexes to be evaluated for their cytotoxic and antimicrobial potential, in addition to their interaction with specific targets such as deoxyribonucleic acid and enzymes.