Síntese e caracterização de complexos de platina(II) com derivados N-alquilados da 1,2-etanodiamina e da 1,3-propanodiamina, potenciais agentes antineoplásicos

Abstract

Several derivatives of the phenylethylamine carry out important functions in numerous biological processes and they possess a great variety of properties pharmacological. On the other hand, platinum complexes (II), as the compound cis-diaminedichloroplatinum(II) cis-[Pt(NH3)2Cl2] (cisplatin), they are effective antitumoral agents. However, the use systemic of the cisplatin in medical clinic has been showing the development of cellular resistance to this drug besides several undesirable effects as nephro and neurotoxicity. The obtaining of new platinum complexes, that can present larger activity antineoplastic and smaller collateral effects have been object of study of several research groups. Inside of that context, we began a synthetic program tends objective the preparation of different ligands derivatives diaminades of the 1,2-ethanediamine and of the 1,3-propanediamine. In two cases, they were prepared ligands contends phenylethyl and phenylpropyl groups. For 1,2-ehanediamine we obtained, also, three new ligands N-alkylated with substituints in the aromatic ring and still, an unpublished ligands synthesized starting from a derivative nafthalenic. Being used of these ligands, we described the synthesis of eight analogs complexes to the cisplatin. The reactions of obtaining of those complexes were made simple way and under soft conditions, supplying the compounds in satisfactory yields.

The compounds like this obtained they were characterized by spectroscopy in area of the infrared, 1H-NMR, 13C-NMR and 195Pt NMR spectra, besides elementary analyses for some compounds.